Further estimate by utilizing of multivariate Cox regression analysis demonstrated that tumor invasion depth (HR, 6.186; 95% CI, 1.836–20.846; P = 0.003), distant metastasis (HR, 2.812; 95% CI, 1.259–6.283; P = 0.012), TNM stage (HR, 2.484; 95% CI, 1.044–5.914; P = 0.040), and STING expression (HR, 1.882; 95% CI, 1.136–3.115; P = 0.014) were independent predictors for overall survival of gastric cancer patients (Fig. 3a). Here, STING1 is linked to gastric cancer.