Four have potential homologues in animals and plants: ROGDI (NCU08091) encodes a human protein of unknown function whose mutation results in epilepsy and dementia60, Hyphal endomembrane protein-3 (HEP-3, NCU03590) is related to Alpha/gamma-adaptin-binding protein p34 of metazoans61, suggesting a role in clathrin-mediated protein sorting, and Vezatin (NCU09240) is involved in focal adhesions in animals62 and has recently been shown to have a role in hyphal polarity63. The gene discussed is AAGAB; the disease is epilepsy.