Importantly, suppression of PFKP significantly potentiated cancer cell survival and clonogenic capacity under metabolic stress (Fig. 5c,d), and RNAi-resistant PFKP expression vector could successfully attenuate the survival and clonogenic potential of cancer cells induced by shRNA-mediated PFKP knockdown (Supplementary Fig. 6f,g). Here, PFKP is linked to cancer.