AKT1 and invasive breast carcinoma: Given the role of DHX9 in AKT activity, we interrogated the Cancer Genome Atlas-invasive breast carcinoma data set at cBioportal ( http://www.cbioportal.org/)37, 38 and found that DHX9 was upregulated in 21% of 1,091 cases (Supplementary Fig. 16A, top).