We demonstrate for the first time, to our knowledge, that VLDP selectively enhances Treg STAT‐5 phosphorylation and subsequently up‐regulates functional molecules cytotoxic T lymphocyte antigen‐4 (CTLA‐4), CD25, FoxP3 and Treg anti‐apoptosis marker Bcl‐2 in AILD. The gene discussed is CTLA4; the disease is angioimmunoblastic T-cell lymphoma.