HNF1A and diabetes mellitus: Amongst the >150 common variant signals for diabetes (all types) identified in genome-wide association studies (GWAS), there are examples of loci that influence each of the following processes: HLA loci for autoimmunity, HNF1A and WFS1 for islet development, CDKN2A for islet senescence, KLF14 and PPARG for adipogenesis, FTO for obesity, KCNJ11 for islet function and so on [15, 16].