In the past decade, several studies have reported that netrin-1 is up-regulated in several types of cancer19, 21, 22, 23, 24 and cancer-associated inflammatory diseases conferring cells with a selective advantage regarding survival and proliferation.25, 26, 27 Netrin-1 is upregulated in cancers in general and in cancer-associated associated inflammatory diseases. This evidence concerns the gene NTN1 and cancer.