CP and acute kidney injury: The kidney tissue section of the NC mice showed an apparent normal structure (Fig. 1A) while that of the LPS mice showed significant degeneration and necrosis of tubular epithelial cell and diaphanous tubular cast (Fig. 1B); no significant pathological changes were observed in HLJDD, RC, RS, CP, and FG groups (Fig. 1C–G), which indicated that HLJDD and its component herbs could remarkably alleviate LPS‐induced AKI.