HK2 and neoplasm: As we expected, we detected a strong negative correlation between miR-143 and HK2 in oral tumor tissues: the expression of HK2, which is associated with tumor aggressiveness [17] was up-regulated in high metastasis oral tumor species (Figure 6D) compared with low metastasis tumors, indicating that HK2 may be associated with metastasis in OSCC; in contrast, the expressions of miR-143 were significantly down-regulated in high metastasis tumors (Figure 6E), indicating miR-143 might be a therapeutic target for the treatments of metastasis OSCC tumor by targeting HK2.