Decorin functions as a tumor repressor, inhibiting cancer growth, migration, and angiogenesis via down-regulation of the oncogenes Myc, β-catenin (in a glycogen synthase kinase 3β-independent manner), and hypoxia-inducible factor 1, α subunit (43, 47, 71, –, 74). The gene discussed is DCN; the disease is neoplasm.