APOE  has been associated with an increased likelihood of developing AD.61–63 Gender differences regarding the prevalence of AD have also been studied.64, 65 Since the BLME models and inference derivation presented in this paper are the first of their kind, the objective of this analysis is to demonstrate probable diagnosis trajectories conditional on very broad, non-group-specific prevalence rates. The gene discussed is APOE; the disease is Alzheimer disease.