NNMT and atherosclerosis: Until now, there has been only one animal‐based study that examined the effects of hepatic NNMT activity and plasma me‐NAM levels in the development of atherosclerosis.10 Mateuszuk et al10 found that hepatic NNMT activity and plasma me‐NAM levels increased by more than 2‐fold in apolipoprotein‐E/LDL double knockout mice compared with controls, and they were associated with the progression of atherosclerosis.