CASP3 and myocardial infarction: The MI/R mice received Mdivi-1 administration exhibited suppressed myocardial apoptosis as indicated by decreased apoptosis index (10.3 ± 2.9 vs. 30.6 ± 3.8% in MI/R group, P < 0.01, Fig. 6a) and caspase-3 activity (2.5 ± 0.26 vs. 3.9 ± 0.21 in MI/R group, P < 0.01, Fig. 6b).