It was found that inhibition of Drp1 significantly reduced infarct size and serum cardiac troponin I activity in MI/R mice without diabetes (Infarct size: 21.6 ± 2.7 vs. 35.1 ± 3.8% in MI/R without diabetes; cTnI: 18.3 ± 2.4 vs. 39.2 ± 3.6 ng/mL in MI/R without diabetes, n = 5, P < 0.05 or P < 0.01). The gene discussed is DNM1L; the disease is myocardial infarction.