Observations that the saliva of ticks, e.g., Ixodes scapilaris and Boophilus microplus, functions as an inhibitor of angiogenesis [198] and that the tick-derived substance ‘ixolaris’ “may block tumor growth of human cell models with ectopic FVIIa expression through inhibition of direct TF-FVIIa-PAR2 signaling” [199] underscore the conclusion that a huge number of bioactive proteins would be present in sanguivorous animals [200]. Here, TF is linked to neoplasm.