It has shown that Nrf-2 and its target anti-oxidant genes such as HO-1 has a critical role in the mechanism against oxidative stress and induced anti-oxidant mechanism that is assumed is beneficial in AD [45], while, Kanninen et al. report states that nuclear translocation of Nrf-2 increased the HO-1 expression [46]. The gene discussed is NFE2L2; the disease is Alzheimer disease.