The mean serum IF1 concentration was also found to be lower in patients with CHD (0.43 mg/L, p < 0.001) than in control subjects without CHD (0.53 mg/L, p < 0.001), and was significantly correlated with CHD after adjusting for plasma HDL and apoA-I (p < 0.001) [12]. This evidence concerns the gene APOA1 and coronary artery disorder.