From a clinical perspective, recent evidence was brought that overexpression of IF1 in hepatocellular carcinoma (HCC) is a poor prognostic indicator, and that this cancer displays a larger degree of angiogenesis, more pronounced active epithelial-mesenchymal transition, and more frequent metastasis than HCC tumors that express normal levels of IF1 [14]. The gene discussed is ATP5IF1; the disease is cancer.