Furthermore, it was supposed that an increased expression of JAB1 correlates with athero-progression [10], because Constitutive photomorphogenesis 9 (COP9) signalosome complex unit 5 (CSN5) was found in endothelial cells and MΦ of human atherosclerotic lesions [10–12] and is involved in the regulation of protein stability and protein degradation [13–15]. Here, COPS5 is linked to Atherosclerotic lesion.