A significant relationship was found between the ER/PgR status and the age of patients (p = 0.026); and between the ER/PgR status and the tumor grade of breast cancer (p = 0.0004), while the correlations of the ER/PgR status with the menopausal status (p = 0.149) and with the histologic type (p = 0,523) were not statistically significant (Table 3). This evidence concerns the gene ESR1 and neoplasm.