F2R and non-small cell lung carcinoma: The commonly used differentiation marker for fibroblasts ACTA2 (gene encoding for alpha-smooth muscle actin, α-SMA [22]) and markers for prominent constituents of ECM deposition Collagen, type I, alpha (COL1A1) and Fibronectin (FN1) were also all correlated with PAR-1 gene expression in the NSCLC specimens (all p < 0.01).