The lack of colorectal cancer‐associated RRAS or RRAS2 mutations led us to search for additional human orthologues of yeast Ras1 and Ras2. The N‐terminal regions of human Ras proteins undergo frequent colorectal cancer‐associated hotspot mutations at codons 12, 13, and 61, and this region does share homology with yeast Ras1 and Ras2 (Fig. S1A) and is closely related to KRAS (Fig. S1B). This evidence concerns the gene RRAS and colorectal cancer.