Mechanistically, we showed that MYC, a transcriptional factor involved in many cancers (Dang, 2012) and a well‐known substrate of MAPK/ERK (Hayes et al., 2016; Wu et al., 2007), facilitates IR‐induced DSB repair through regulation of HRR in KRAS‐mutant cells. The gene discussed is MYC; the disease is cancer.