BRCA1 and colorectal cancer: Importantly, we found that this large network is substantially linked to DSB repair by HRR (P = 3.0 × 10−4), the BRCA1‐mediated DDR (P = 4.06 × 10−4), mismatch repair in eukaryotes (P = 3.95 × 10‐4) as well as E1F2 signaling (P = 3.73 × 10−4) (Fig. 1A), consistent with a recently published report on wild‐type (WT) HRAS and NRAS promoting mutant KRAS‐driven tumorigenesis by modulating the DDR in colorectal cancer cells (Grabocka et al., 2014).