CD4 and immune system disorder: Moreover, the ability of CD4+ T-cells to secrete immunomodulatory cytokine IL10 in response to PHA+LPS implicated that SCI patients does not have any Treg dependent dysregulation compared to healthy PBMCs (Fig 1C), indicating that the cell sources of suspected immune dysfunction is not mainly due to impaired B cell, pDC or altered CD4+ Treg activity (Fig 1).