HPS5 and Down syndrome: Other syndromes that lead to generalized decreased or abnormal pigmentation include the oculocutaneous albinism types 1–4 syndromes (TYR, OCA2, TYRP1, and SLC45A2, respectively) [Montoliu et al. 2014], Hermansky-Pudlak syndromes (HPS1, AP3B1, HPS3, HPS4, HPS5, HPS6, DTNBP1, BLOCK1S3, and PLDN) [67], Chediak-Higashi syndrome (LYST), Griscelli syndrome (MYO5A, RAB27A, and MLPH), and Menkes syndrome (ATP7A) [68].