Interestingly, starting after 24 h of treatment with conditioned media (CM) derived from peritoneal macrophages of Nur77+/+ and Nur77-/- mice, we observed that the conditioned media derived from Nur77-/- peritoneal macrophages (CM2) significantly enhanced the migratory ability of CT26 mouse colon carcinoma cells compared with the conditioned media derived from Nur77+/+ peritoneal macrophages (CM1) (Fig 1E). Here, NR4A1 is linked to colon carcinoma.