In a previous prospective study, most IFN-α-induced depression achieved remission within 12 weeks after the end of the IFN therapy.15 Our study included 282 patients who developed depressive disorders during the IFN-α therapy period, after the exclusion of 3255 patients with depressive disorders and antidepressant use within the year preceding IFN therapy. This evidence concerns the gene IFNA1 and major depressive disorder.