Continuation treatment is important in depressive disorders in patients who have responded to initial antidepressant therapy.40 For patients who had a depressive episode during IFN-α therapy, the treatment choice was the early discontinuation of IFN-α therapy41 and antidepressant therapy.42 The long-term management of IFN-α-induced depressive disorder is uncertain,43 and further studies are needed to consolidate the potential prevention strategies with drugs and non-drugs for this high-risk group. Here, IFNA1 is linked to depressive disorder.