IFNA1 and depressive disorder: However, there was a preponderance of women in depression recurrence,38 and female sex was found to be an independent predictor of the emergence of major depression during HCV therapy; women more frequently reported depressive symptoms and more frequently initiated antidepressant medication.24 In our cohort, female IFN-α-induced depression patients had a lower full remission rate, and only 81 female subjects (51.2%) were enrolled in the cohort (compared with 75 male subjects (60.5%); Table 5).