ADORA2B and Schnyder corneal dystrophy: In contrast, due to the mutation of β-haemoglobin in sickle cell disease (SCD; HbS), elevated adenosine signalling via ADORA2B-induced production of 2,3-BPG in the SCD erythrocyte becomes detrimental because it triggers deoxygenated HbS, polymerization and eventually sickling, a central pathophysiology of SCD20.