Further, the leptin level in each PSEs intervention group was similar to that in the NC group and was slightly higher than that in the HF group (Fig. 4E), and the adiponectin levels were significantly lower in all PSEs intervention groups than in the NC group (P < 0.05), but they remained 7–10% higher than that in the HF group (Fig. 4F). The gene discussed is ADIPOQ; the disease is hydrops fetalis.