It has been confirmed that, FOSL1 is a kind of proto-oncogene, and elevated expression of FOSL1 is detected in multiple human carcinomas, including colon adenocarcinoma, ovarian cancer, breast cancer, head and neck, lung and esophageal squamous cell carcinoma, etc9, 12. Here, FOSL1 is linked to esophageal squamous cell carcinoma.