Here, we show that reintroduction of this EPH receptor into colon cancer cells with low levels of either wild type (LS174T) or mutant (DLD1) EPHA3 and that express the preferred EPHA3 ligand (Ephrin A5), has no effects on the growth of cancer cells on a solid substrate, soft agar or when grown as subcutaneous xenografts in immunodeficient NOD/SCID mice. Here, EFNA5 is linked to malignant colon neoplasm.