EPHA3 and malignant colon neoplasm: Consistently, reintroduction of EPHA3 in colon cancer cells did not affect their metastatic potential in an experimental model of lung metastasis and no differences were observed in the expression of EPHA3 in primary Dukes C tumors and matched lymph node metastases, indicating that EPHA3 does not play a major role in the metastatic process of these tumors.