Overexpression of the EPHA3D806N mutant protein in DLD1 or LS174T cells, or deletion of the endogenous mutant EPHA3 in SW48 cells had no effect on cell proliferation (Fig. 6A–C) or motility (Fig. 6D–F), indicating that these EPHA3 mutations observed in colon tumors do not confer a growth/motility advantage. Here, EPHA3 is linked to colonic neoplasm.