The signaling modules responsible for the flow-sensing response involve a number of proteins located in the cell membrane, cilium and/or at the ciliary base, including polycystin-1 (PC-1) and the ion channel polycystin-2 (PC-2), encoded by the genes mutated in patients with autosomal dominant polycystic kidney disease (ADPKD) [4, 5]. Here, PKD2 is linked to autosomal dominant polycystic kidney disease.