KLK3 and posterior cortical atrophy: First and foremost, accurate PSA information was not available in the SEER database prior to 2010 and neither was RT dose, EBRT modality (3D conformal RT vs. IMRT vs. stereotactic body RT) and BT modality (LDR vs. high dose rate). Another important limitation of the SEER database for PCa is the lack of ADT information.