APP and Alzheimer disease: Rezai-Zadeh et al. demonstrated that epigallocatechin-3-gallate (EGCG), the main polyphenolic constituent of green tea through its beta-secretase activity, reduced Aβ aggregation in neuron-like cells (N2a), transfected with the human “Swedish” mutant amyloid precursor protein (APP) and in primary neurons derived from Swedish mutant APP-overexpressing Tg APPSW transgenic mice model of AD [90].