SKP2 and lip and oral cavity carcinoma: It has been reported that CAPE inhibits proliferation [14, 15, 23, 24], COX-2 activity [52, 53], phosphoinositide 3-kinase-protein kinase B (PI3K-Akt) signaling, and Skp2-F-box protein family, responsible for downregulation of p27Kip1 protein [14] in human oral cancer cells.