In CD patients, the mutant allele (T) and genotype (AT+TT) of FUT2 A385T were less prevalent in patients with ileocolonic CD than in colonic CD (41.67% versus 59.41%, P = 0.001, OR = 0.488, and 95% CI = 0.324–0.734; 63.33% versus 83.17%, P = 0.002, OR = 0.350, and 95% CI = 0.178–0.686, resp). Here, FUT2 is linked to Cowden disease.