PPARG and colorectal neoplasm: Finally, miR-145, which is downregulated in colorectal cancer cells (Caco2, Sw480, HCT116, and HT29) and colorectal tumor tissues, is induced by the PPARγ agonist (i.e., rosiglitazone) via direct binding of PPARγ to PPRE in the promoter encoding pre-miR-145 [96, 131].