In vitro analyses of hepatoma cell lines (HepG2 and murine AML12 cells) exposed to fatty acids as a surrogate model of steatosis further confirm an upregulation of miR-199a-5p, which in turn downregulates PPARα and caveolin-1 thereby promoting abnormal cellular redox equilibrium and fatty acids intracellular accumulation [37]. This evidence concerns the gene PPARA and hepatocellular carcinoma.