Previous work by our team has shown that CD8+CD28low Treg can prevent intestinal inflammation in a well-established experimental colitis model where pathology is induced by the adoptive transfer of naïve CD4+CD45RBhigh T cells into lymphopenic animals [recombinase activating gene 2 (RAG2) deficient or severe combined immunodeficiency mice (23, 24)]. This evidence concerns the gene CD8A and colitis.