Increased levels of pro-inflammatory cytokines [such as tumor necrosis factor alpha (TNFα), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1)], adipokines, and autoantibodies are associated with the progression of endothelial dysfunction toward atherosclerosis development (6). The gene discussed is CCL2; the disease is endothelial dysfunction.