RTN4 and amyotrophic lateral sclerosis: Overexpression of reticulon-1C (Rtn1-C) or reticulon-4A (NogoA) induces a new localization of PDIs in an ALS neuronal cell model and knockdown of NogoA accelerates motor neuron degeneration in SOD1G93A transgenic mice (Yang et al., 2009; Bernardoni et al., 2013).