Although the mechanism underlying SFA-induced metabolic dysregulation in fish liver is unclear, several studies in mammals have suggested that the effected fatty acid oxidation and insulin resistance resulted from the regulation of stearoyl-CoA desaturase (SCD) (Yokoyama et al., 2012; Miyazaki et al., 2009), insulin receptor (Yang et al., 2014a) and insulin receptor substrate (Yang et al., 2014b) modification and expression. The gene discussed is INSR; the disease is Insulin resistance.