PGF and preeclampsia: A recent study of women with clinically suspected disease demonstrated that an sFlt-1:PlGF ratio cutoff of 38 provided clinically useful prediction of the risk of preeclampsia.4 Higher sFlt-1:PlGF ratios, namely >85 at 28 weeks of gestational age (wkGA) and >110 at 36 wkGA, have been shown to be more strongly associated with the risk of preeclampsia.5 However, evidence for the diagnostic effectiveness of the ratio in screening women without clinical suspicion of the disease is poor.