Interestingly, three other Elongator subunits, ELP2 to ELP4, have each been associated with CNS disorders (Nguyen et al., 2010): ELP2 and ELP4 have been implicated in intellectual development disorders (Cohen et al., 2015; Franic et al., 2015; Addis et al., 2015) and epilepsy (Gkampeta et al., 2014; Reinthaler et al., 2014; Strug et al., 2009), and ELP3 with amyotrophic lateral sclerosis (Simpson et al., 2009; Kwee et al., 2012). The gene discussed is ELP4; the disease is amyotrophic lateral sclerosis.