TUBA1A and Fabry disease: IC/C mice grow normally while littermate Tuba1a-Cre;IC/C CKO mice develop a progressive degenerative condition that shares some of the classic hallmarks of human FD: they are smaller than their control littermates, develop kyphosis, and have a slow and unsteady gait (Movies 1 and 2; Fig. 3A), with approximately 50% of CKO mice dying by 5 months of age, often suddenly.