Aggregated GAPDH in the brain is also amyloidogenic, and GAPDH amyloidal aggregates colocalize with Lewy bodies in Parkinson's disease (18, 19) and with senile plaques and neurofibrillary tangles in Alzheimer's disease (20, –, 23). This evidence concerns the gene GAPDH and early-onset autosomal dominant Alzheimer disease.