MS4A1 and lymphoma: As mentioned above and envisioned in Scheme 1, in this paper we aim to evaluate whether (a) it is possible to design an intracellular pH-responsive and targeted drug delivery system based on MSNs, (b) targeted drug delivery system are able to selectively adhere to CD20 antigen positive lymphoma B cells and (c) whether molecules (i.e., DOX) can be selectively delivered to CD20 antigen positive lymphoma B cells upon binding with RDMSNs via the receptor-mediated endocytosis pathway for improving the therapeutic index.