APOE and atherosclerosis: Some results showed increased atherosclerosis in B cell deficient LDL receptor-deficient (Ldlr−/−) mice, suggesting an atheroprotector role, whereas others have reported that the depletion of B cells through the use of specific monoclonal antibodies against CD20 molecule, reduce the development of atherosclerosis in both, apolipoprotein E single knockout (Apoe−/−) and Ldlr−/− mice, showing an atherogenic effect [35, 36].