Apoe−/−mice with a deficiency in the γ chain expression of FcγR, and fed with high fat diet, exhibited a limited development and progression of atherosclerosis, suggesting a proatherogenic effect that could be associated with the loss of FcγRI and FcγRIIIA, and the overexpression of the inhibitory FcγRIIB characteristic of this mouse model. The gene discussed is FCGR2A; the disease is atherosclerosis.