The mice that mounted strong GagL85–93-specific CD8+ T cell responses showed a strong reduction in viral loads in the plasma on day 10 and in the spleens on day 21 after FV challenge infection (Fig. 2d, e); mice that were immunized with Ad.pIXgp70 followed by Ad.TxnGagL had mostly very high viral loads. This evidence concerns the gene CD8A and infection.