Then, having demonstrated that JN-DSRCT-1 cells are particularly sensitive to trabectedin, with a strong G2/M block, we investigated whether the drug affected the binding of EWS-WT1 chimera to DNA sequence within target promoters, like the FUS-CHOP chimera in MLS disease or the EWS-FLI1 in Ewing Sarcoma [8, 20]. This evidence concerns the gene WT1 and Ewing sarcoma.