The introduction of direct oral anticoagulants (DOACs) has had a considerable impact on the world of oral anticoagulation: In Germany, dabigatran, a direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor, were the first DOACs to be approved for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and at risk of stroke [9]. Here, F10 is linked to Stroke.