SRI and staphylococcal infection: Each of these phages carried a set of genes encoding putative virulence factors: the small secreted proteins (Chp and Scn) involved in immune evasion, a leukocidin-like protein, the small RNA (named SprD) that has been shown to significantly contribute to disease in an animal model [26], a tyrosine recombinase (XerC) linked to biofilm-associated staphylococcal infections and acute bacteremia [27], and an ATP-dependent Clp protease that has been shown to have a major impact on virulence, the stress response and physiology in S. aureus [28] (Table 2).