GAPDH and cancer: It has been described that downregulation of hsp70 levels leads to increased sensitivity towards apoptosis-inducing agents, induces differentiation and cell death in cancer cells [70], and diminishes cell survival [71], although the strong repression detected in our study (together with those detected for rpL13, EcR, CYP4G, and GAPDH) could be the result of a general protective cell response consistent in maintaining a general low transcriptional profile in the presence of a sustained damage [72].