Cryptococcal meningitis (CM), an opportunistic infection (OI), is a major cause of mortality and morbidity in HIV-positive patients in South Africa due to high local HIV prevalence that ranges between 16.9 and 37.4% across nine provinces (national prevalence of 29.5% is recorded)[1].CM primarily affects patients with a CD4 < = 100 cells/μl [2,3], not yet on antiretroviral therapy (ART) or recently initiated on ART. The gene discussed is CD4; the disease is cutaneous mastocytosis.