KLF6 and Familial prostate cancer: Interestingly, overexpression of KLF6-sv1 leads to a significant increase in the percent of cells in S-phase, cellular proliferation and cell invasion, consistent with the proposed role of KLF6-sv1 as an oncogenic variant, which drives metastasis and is associated with poor survival in prostate cancer.25 Our data suggest that KLF6-sv1-mediated oncogenic functions do not require translocation into the nucleus and repression of NF-κB-negative regulators.