The enhanced ability of KLF6-wt expressing cells to activate an aberrant/incomplete neural-like differentiation program is in line with a previously reported role of NF-κB in mesenchymal differentiation of glioblastoma-initiating cells.52 Interestingly, blockade of NF-κB in these cells is also associated with increased senescence, similarly to what we observed in our study.52 One could argue that senescence occurs as a consequence of activating an aberrant KLF6-mediated neural differentiation pathway in glioblastoma cells growing under proliferative conditions. This evidence concerns the gene KLF6 and glioblastoma.