KLF6 and liposarcoma: In accordance with this hypothesis, KLF6 has been recently shown to be silenced by increased trimethylation of histone H3 at Lys9 (H3K9me3) levels in dedifferentiated liposarcomas.46 As such, further studies would be required to determine whether additional epigenetic mechanisms silence KLF6 in glioblastoma and/or whether they are alternative to genomic alterations.