NFKBIA and neoplasm: The NF-κB transcription factor family is oncogenic through suppression of programmed cell death, and promotion of tumor growth and invasion.1 In tumors, NF-κB can be activated by mutations in its own genes or in its regulating genes.2 In the canonical pathway, NFKBIA (IκBα)3 interacts and sequesters the p65/p50 NF-κB heterodimer in the cytoplasm.